DIFFERENTIAL MOBILITY OF THE N-TERMINAL HEADPIECE IN THE LAC-REPRESSOR PROTEIN

被引:77
作者
WADEJARDETZKY, N [1 ]
BRAY, RP [1 ]
CONOVER, WW [1 ]
JARDETZKY, O [1 ]
GEISLER, N [1 ]
WEBER, K [1 ]
机构
[1] MAX PLANCK INST BIOPHYS CHEM,D-3400 GOTTINGEN,FED REP GER
关键词
D O I
10.1016/0022-2836(79)90129-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is shown by resolution enhancement and relaxation studies of the 360 MHz 1H nuclear magnetic resonance spectra of the lac-repressor of Escherichia coli and the two fragments derived from it by limited tryptic digestion (the N-terminal headpiece and remaining T-core) that the majority of the relatively mobile residues in the intact lac-repressor are located in the headpiece. Although nuclear magnetic resonance data clearly indicate that the headpiece is a highly structured entity, even when isolated, it is a more mobile part of the repressor than the T-core. © 1979.
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页码:259 / 264
页数:6
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