DIFFERENTIAL MOBILITY OF THE N-TERMINAL HEADPIECE IN THE LAC-REPRESSOR PROTEIN

被引：77

作者：

WADEJARDETZKY, N ^{[1
]}

BRAY, RP ^{[1
]}

CONOVER, WW ^{[1
]}

JARDETZKY, O ^{[1
]}

GEISLER, N ^{[1
]}

WEBER, K ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,D-3400 GOTTINGEN,FED REP GER

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1979年 / 128卷 / 02期

关键词：

D O I：

10.1016/0022-2836(79)90129-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is shown by resolution enhancement and relaxation studies of the 360 MHz 1H nuclear magnetic resonance spectra of the lac-repressor of Escherichia coli and the two fragments derived from it by limited tryptic digestion (the N-terminal headpiece and remaining T-core) that the majority of the relatively mobile residues in the intact lac-repressor are located in the headpiece. Although nuclear magnetic resonance data clearly indicate that the headpiece is a highly structured entity, even when isolated, it is a more mobile part of the repressor than the T-core. © 1979.

引用

页码：259 / 264

页数：6

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