ISOLATION OF 5,8-OXYRETINOIC ACID FROM RAT INTESTINAL-MUCOSA

被引：18

作者：

MCCORMICK, AM

NAPOLI, JL

SCHNOES, HK

DELUCA, HF

机构：

[1] Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 192卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0003-9861(79)90128-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polar metabolites of retinoic acid accumulate in the intestine of vitamin A-deficient rats 3 h after administration of 450 μg of [11,12-3H]retinoic acid. Using new Chromatographic procedures developed for the purification of vitamin A metabolites, a major polar derivative of retinoic acid was isolated from intestine in pure form as its methyl ester and positively identified as 5,8-oxyretinoic acid. © 1979.

引用

页码：577 / 583

页数：7

共 40 条

[1]

CRAIN FD, 1967, J LIPID RES, V8, P249

[2]

DELUCA L, 1969, AM J CLIN NUTR, V22, P1059

[3] RNA METABOLISM IN RAT INTESTINAL MUCOSA OF NORMAL AND VITAMIN-A-DEFICIENT RATS [J].

DELUCA, L ;

KLEINMAN, HK ;

LITTLE, EP ;

WOLF, G .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1971, 145 (01) :332-&

[4]

DELUCA L, 1969, J BIOL CHEM, V244, P701

[5]

DELUCA L, 1972, CANCER, V30, P1326, DOI 10.1002/1097-0142(197211)30:5<1326::AID-CNCR2820300527>3.0.CO

[6]

2-J

[7] RAPID CONVERSION OF RETINAL (VITAMIN A ALDEHYDE) TO RETINOIC ACID (VITAMIN A ACID) IN LIVING RAT [J].

DESHMUKH, DS ;

MALATHI, P ;

GANGULY, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 107 (01) :120-&

[8] THE BIOLOGICAL FUNCTION OF VITAMIN-A ACID [J].

DOWLING, JE ;

WALD, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1960, 46 (05) :587-608

[9] IDENTIFICATION OF METABOLITES OF RETINAL AND RETINOIC ACID IN RAT BILE [J].

DUNAGIN, PE ;

ZACHMAN, RD ;

OLSON, JA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 124 (01) :71-&

[10] RETINOYL BETA-GLUCURONIC ACID - A MAJOR METABOLITE OF VITAMIN A IN RAT BILE [J].

DUNAGIN, PE ;

MEADOWS, EH ;

OLSON, JA .

SCIENCE, 1965, 148 (3666) :86-&

← 1 2 3 4 →