PLASMA-CONCENTRATION PROFILES AND ANTIHYPERTENSIVE EFFECT OF CONVENTIONAL AND EXTENDED-RELEASE FELODIPINE TABLETS

被引：29

作者：

BLYCHERT, E ^{[1
]}

WINGSTRAND, K ^{[1
]}

EDGAR, B ^{[1
]}

LIDMAN, K ^{[1
]}

机构：

[1] AB HASSLE,PHARMACEUT RES & DEV,S-43183 MOLNDAL,SWEDEN

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 29卷 / 01期

关键词：

D O I：

10.1111/j.1365-2125.1990.tb03600.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The rate and extent of felodipine absorption from an oral solution, conventional and extended‐release tablets were investigated in two groups of healthy volunteers (n = 18 + 15). 2. The antihypertensive effect of felodipine conventional tablets twice daily (n = 71) and extended‐release tablets once daily (n = 76) were compared in a parallel‐group study in hypertensive patients. 3. As from a solution, felodipine was completely absorbed from the two solid dosage forms. The rate of absorption increased in the order extended‐release tablets, conventional tablets, solution. 4. The extended‐release tablet gave more sustained plasma concentrations than the conventional tablet. 5. The extended‐release tablet given once daily gave similar blood pressure control to the conventional tablet given twice daily. 1990 The British Pharmacological Society

引用

页码：39 / 45

页数：7

共 13 条

[1] Ahnoff M, 1984, J Pharm Biomed Anal, V2, P519, DOI 10.1016/0731-7085(84)80055-2
[2] COMPARISON OF HIGH-SELECTIVITY GAS-CHROMATOGRAPHIC METHODS, INCLUDING COLUMN SWITCHING, FOR THE DETERMINATION OF FELODIPINE IN PLASMA
AHNOFF, M
ERVIK, M
JOHANSSON, L
[J]. JOURNAL OF CHROMATOGRAPHY, 1987, 394 (03): : 419 - 427
[3] CLINICAL PHARMACOKINETICS OF FELODIPINE - A SUMMARY
EDGAR, B
LUNDBORG, P
REGARDH, CG
[J]. DRUGS, 1987, 34 : 16 - 27
[4] PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES OF FELODIPINE IN HEALTHY-SUBJECTS AFTER VARIOUS SINGLE, ORAL AND INTRAVENOUS DOSES
EDGAR, B
REGARDH, CG
LUNDBORG, P
ROMARE, S
NYBERG, G
RONN, O
[J]. BIOPHARMACEUTICS & DRUG DISPOSITION, 1987, 8 (03) : 235 - 248
[5] FELODIPINE KINETICS IN HEALTHY-MEN
EDGAR, B
REGARDH, CG
JOHNSSON, G
JOHANSSON, L
LUNDBORG, P
LOFBERG, I
RONN, O
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 38 (02) : 205 - 211
[6] Felle K, 1984, J Pharm Biomed Anal, V2, P527, DOI 10.1016/0731-7085(84)80056-4
[7] TREATMENT OF ESSENTIAL-HYPERTENSION WITH FELODIPINE IN COMBINATION WITH A DIURETIC
HEDNER, T
SAMUELSSON, O
SJOGREN, E
ELMFELDT, D
[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 30 (02) : 133 - 139
[8] HEDNER T, 1987, J CARDIOVASC PHAR S1, V10, P177
[9] LANDAHL S, 1989, IN PRESS CLIN PHARMA
[10] MACLEAN D, 1986, BRIT J CLIN PHARMACO, V21, P621

← 1 2 →