PAIN AND TENDERNESS IN HUMAN TEMPORAL MUSCLE INDUCED BY BRADYKININ AND 5-HYDROXYTRYPTAMINE

被引：67

作者：

JENSEN, K

TUXEN, C

PEDERSENBJERGAARD, U

JANSEN, I

EDVINSSON, L

OLESEN, J

机构：

[1] MALMO GEN HOSP, DEPT EXPTL RES, S-21401 MALMO, SWEDEN

[2] UNIV LUND HOSP, DEPT INTERNAL MED, S-22185 LUND, SWEDEN

来源：

PEPTIDES | 1990年 / 11卷 / 06期

关键词：

ALGOMETER; BRADYKININ; 5-HYDROXYTRYPTAMINE; HUMAN; MUSCULUS TEMPORALIS; NOCICEPTION; PAIN; PRESSURE-PAIN THRESHOLD;

D O I：

10.1016/0196-9781(90)90141-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pain was induced in 19 healthy individuals by double-blind injections into the temporal muscle of 0.2 ml of physiological saline with or without active substances added. 5-Hydroxytryptamine (2 nmol) caused pain similar to saline, bradykinin (2 nmol) only insignificantly more pain (0.05 < p < 0.1), while a mixture of the two substances in half dosage (1 nmol + 1 nmol) caused pain significantly above saline (p < 0.01). Variations in the response to saline did not permit a conclusion to be made on the question of induced tenderness. However, the mixture of the two substances appeared to lower the pressure-pain threshold as measured by pressure algometer (p < 0.05).

引用

页码：1127 / 1132

页数：6

共 35 条

[1] RESPONSES OF NEURONS IN FELINE TRIGEMINAL SUBNUCLEUS CAUDALIS (MEDULLARY DORSAL HORN) TO CUTANEOUS, INTRAORAL, AND MUSCLE AFFERENT STIMULI [J].