AFFINITY OF 22-OXA-1,25(OH)2D3 FOR 1,25-DIHYDROXYVITAMIN-D RECEPTOR AND ITS EFFECTS ON THE SYNTHESIS OF OSTEOCALCIN IN HUMAN OSTEOSARCOMA CELLS

被引：18

作者：

VALAJA, T

MAHONEN, A

PIRSKANEN, A

MAENPAA, PH

机构：

[1] Department of Biochemistry and Biotechnology, University of Kuopio, SF-70211 Kuopio

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 02期

基金：

芬兰科学院;

关键词：

D O I：

10.1016/0006-291X(90)90377-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new 1,25-dihydroxyvitamin D3 analog, 22-oxa-1,25(OH)2D3, which may have pharmaceutical use, e.g., in the treatment of psoriasis, was studied using cultured MG-63 human osteosarcoma cells. We found that the new compound binds to 1,25-hydroxyvitamin D receptors and regulates receptor mRNA levels like the natural ligand. Our results also indicate that 22-oxa-1,25(OH)2D3 induces the synthesis of osteocalcin and the activity of alkaline phosphatase in MG-63 cells through a receptor-mediated process identically with 1,25(OH)2D3. © 1990.

引用

页码：629 / 635

页数：7

共 23 条

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