HUMAN SYNOVIAL-CELLS SECRETE A 39-KDA PROTEIN SIMILAR TO A BOVINE MAMMARY PROTEIN EXPRESSED DURING THE NONLACTATING PERIOD

被引：87

作者：

NYIRKOS, P ^{[1
]}

GOLDS, EE ^{[1
]}

机构：

[1] MCGILL UNIV,MONTREAL H3G 1A6,QUEBEC,CANADA

来源：

BIOCHEMICAL JOURNAL | 1990年 / 269卷 / 01期

关键词：

D O I：

10.1042/bj2690265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By SDS/PAGE analysis we have observed that human synovial cell monolayers secrete a prominent 39 kDA protein which could not be detected in skin and lung fibroblasts. This protein was purified to homogeneity by heparin-Sepharose chromatography and reverse-phase h.p.l.c. The N-terminal sequence was found to be almost identical to that of a recently described bovine protein detected in the mammary secretions during the involutionary phase of the lactational cycle. Characterization of this 39 kDa protein may provide a useful marker for classification of connective tissue cells.

引用

页码：265 / 268

页数：4

共 10 条

[1] RHEUMATOID SYNOVIAL CELL MORPHOLOGIC CHANGES INDUCED BY A MONONUCLEAR CELL FACTOR IN CULTURE [J].