CALCIUM CALMODULIN-DEPENDENT PHOSPHORYLATION AND THE EFFECT OF CADMIUM IN CULTURED FISH CELLS

被引：16

作者：

BEHRA, R

GALL, R

机构：

[1] Swiss Federal Institute for Water Resources and Water Pollution Control (EAWAG)

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1991年 / 100卷 / 1-2期

关键词：

D O I：

10.1016/0742-8413(91)90152-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Calmodulin constitutes approximately 0.7% of the soluble protein in rainbow trout gonadal cells (RTG-2). 2. Calcium-dependent phosphorylation of endogenous proteins was examined in vitro in cytosol fractions of RTG-2 cells. Phosphorylation of numerous proteins was stimulated by calmodulin and calcium, and inhibited by the calmodulin-binding phenothiazine, trifluoperazine. 3. Cadmium was as effective as calcium in stimulating calmodulin-dependent phosphorylations of endogenous substrates in cytosolic fractions of RTG-2 cells.

引用

页码：191 / 195

页数：5

共 23 条

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