RECOVERY OF CIGUATOXIN FROM FISH FLESH

被引:37
作者
LEWIS, RJ
SELLIN, M
机构
[1] Southern Fisheries Centre, QDPI, Deception Bay, QLD 4508
关键词
D O I
10.1016/0041-0101(93)90407-A
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A mouse bioassay, validated for the quantification of ciguatoxin in up to 20 mg of ether extract from fish flesh, revealed that 63 +/- 14% of spiked ciguatoxin was recovered using a standard extraction procedure. Except for extracts from the least toxic of ciguateric fish (0.1-0.5 nmol ciguatoxin-1/kg fish), signs in mice of intoxication by ciguatoxin (hypothermia to below 33-degrees-C as well as at least severe diarrhoea or lachrymation or hypersalivation) could be distinguished from the toxic reaction that follows administration of ciguatoxin-free ether extracts. Ciguatoxin recovery was similar for four variants of the ether-water partition, with the 2M NaCl/ether partition extracting half the contaminants. The method described is selective for ciguatoxin and could be used to quantify natural levels ciguatoxin in the flesh of fish in the absence of a validated in vitro test.
引用
收藏
页码:1333 / 1336
页数:4
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