RETINOBLASTOMA AQUEOUS-HUMOR - AROMATIC-AMINO-ACIDS

被引：4

作者：

ABRAMSON, DH ^{[1
]}

SENFT, SH ^{[1
]}

SERVODIDIO, CA ^{[1
]}

ELLSWORTH, RM ^{[1
]}

GAMACHE, PH ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,NEW YORK HOSP,NEW YORK,NY 10021

来源：

OPHTHALMIC PAEDIATRICS AND GENETICS | 1993年 / 14卷 / 03期

关键词：

RETINOBLASTOMA; CANCER; AQUEOUS HUMOR; TYROSINE; TRYPTOPHAN; ASCORBATE; CATARACT; EYE; ELECTRODE ARRAY; VANDYLMANDELIC ACID; HOMOVANILLIC ACID;

D O I：

10.3109/13816819309087628

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Aqueous humor from children with retinoblastoma obtained at enucleation and from eyes with adult cataracts were assayed with electrochemical liquid chromatography (Model 5500 Coulochem electrode array system) for metabolites of tyrosine, tryptophan metabolic pathways, catecholamine degradation pathways and ascorbate. More than 20 metabolites were identified in human aqueous for the first time. High levels of ascorbate were found in aqueous of eyes with adult cataracts (254, 336 ng/ml). Tyrosine metabolism in both sets of eyes was through dopamine. Vandylmandelic acid (VMA), homovanillic acid (HVA), and 3-methoxy, 4-hydroxyphenylglycol (MHPG) were all detected in retinoblastoma eyes. Although eyes with either adult cataracts or childhood retinoblastoma convert tryptophan through the serotonin pathway, retinoblastoma eyes metabolize tryptophan-through the kynurenine pathway to a greater degree than adult cataract eyes.

引用

页码：127 / 130

页数：4

共 12 条

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