HUMAN GAMMA-INTERFERON EXPRESSION IN THE MAMMARY-GLAND OF TRANSGENIC MICE

被引：20

作者：

DOBROVOLSKY, VN

LAGUTIN, OV

VINOGRADOVA, TV

FROLOVA, IS

KUZNETSOV, VP

LARIONOV, OA

机构：

[1] MM SHEMYAKIN BIOORGAN CHEM INST,UL MIKLUKHO MAKLAYA 16-10,MOSCOW 117871,RUSSIA

[2] NF GAMALEYA EPIDEMIOL & MICROBIOL,MOSCOW,RUSSIA

来源：

FEBS LETTERS | 1993年 / 319卷 / 1-2期

关键词：

GAMMA-INTERFERON; BETA-LACTOGLOBULIN; HUMAN; OVINE; TRANSGENIC MOUSE; MILK;

D O I：

10.1016/0014-5793(93)80063-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transgenic mice carrying a hybrid gene consisting of ovine beta-lactoglobulin gene sequences and human gamma-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IU/ml. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male.

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收藏

页码：181 / 184

页数：4

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