STEREOCONTROLLED SYNTHESIS OF P-SUBSTITUTED TRIFLUOROMETHYLBENZYLIC ALCOHOL DERIVATIVES OF HIGH OPTICAL PURITY BY THE BAKERS-YEAST REDUCTION

被引：28

作者：

FUJISAWA, T

ICHIKAWA, K

SHIMIZU, M

机构：

[1] Department of Chemistry for Materials, Mie University, Tsu, Mie

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)80234-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselectivity of the bakers' yeast reduction of p-substituted trifluoroacetylbenzene derivatives could be improved by the introduction of some functional groups at the para-position to give the corresponding (R)-trifluoromethyl-substituted benzylic alcohols in high chemical and optical yields. The optically active alcohols obtained were readily converted into optically pure forms by recrystallization.

引用

页码：1237 / 1240

页数：4