GLAUCOMA - CHANGES IN EXTRACELLULAR-MATRIX IN THE OPTIC-NERVE HEAD

被引：64

作者：

HERNANDEZ, MR ^{[1
]}

YE, HQ ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

来源：

ANNALS OF MEDICINE | 1993年 / 25卷 / 04期

关键词：

OPTIC NERVE; GLAUCOMA; EXTRACELLULAR MATRIX; COLLAGEN; ELASTIN;

D O I：

10.3109/07853899309147290

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary open angle glaucoma (POAG), the most common form of glaucoma, is characterized by irreversible loss of axons from the optic nerve. The site of damage to the axons is at the level of the lamina cribrosa in the optic nerve head. it has been hypothesized that structural and biochemical abnormalities in the extracellular matrix (ECM) of the lamina cribrosa underlie the progressive compressive and remodelling of this connective tissue in glaucoma. In this review, we present evidence of specific changes in collagen and elastic fibers, major ECM components in the lamina cribrosa of glaucomatous eyes.

引用

页码：309 / 315

页数：7

共 26 条

[1]

ANDERSON DR, 1969, ARCH OPHTHALMOL-CHIC, V82, P800

[2] THE STRUCTURE OF THE LAMINA-CRIBROSA OF THE HUMAN EYE - AN IMMUNOCYTOCHEMICAL AND ELECTRON MICROSCOPICAL STUDY [J].