T-CELLS FROM THE SMALL-INTESTINAL MUCOSA OF A DR4,DQ7 DR4,DQ8 CELIAC-DISEASE PATIENT PREFERENTIALLY RECOGNIZE GLIADIN WHEN PRESENTED BY DQ8

被引:129
作者
LUNDIN, KEA
SCOTT, H
FAUSA, O
THORSBY, E
SOLLID, LM
机构
[1] NATL HOSP NORWAY,INST TRANSPLANTAT IMMUNOL,OSLO,NORWAY
[2] NATL HOSP NORWAY,IMMUNOHISTOCHEM & IMMUNOPATHOL LAB,OSLO,NORWAY
[3] UNIV OSLO,OSLO,NORWAY
关键词
D O I
10.1016/0198-8859(94)90047-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD is an immunologic disease of the small intestine which is precipitated by ingestion of wheat gliadin. Most patients carry the HLA-DQ (alpha 1(*)0501,beta 1(*)0201) (DQ2) heterodimer. We recently reported that a preponderance of gliadin-specific T cells from the small intestinal mucosa of DQ2-positive CD patients were restricted by this DQ heterodimer. However, a small percentage of CD patients do not carry this DQ heterodimer, and most of them instead carry DQ (alpha 1(*)0301,beta 1(*)0302) (DQ8). Here we report that a majority of gliadin-specific T cells from the small intestinal mucosa of a DR4,DQ7/DR4,DQ8 heterozygous CD patient are restricted by DQ8. Thus, preferential presentation of gliadin-derived peptides to T cells by the CD-associated DQ2 and DQ8 molecules may be an initial and important immunopathogenic step in CD.
引用
收藏
页码:285 / 291
页数:7
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