CIRCULATING HEMATOPOIETIC PROGENITOR CELLS IN POLYCYTHEMIA-VERA - THE IN-VIVO EFFECT OF HYDROXYUREA

被引：7

作者：

CASTELLO, G

LERZA, R

CERRUTI, A

CAVALLINI, D

BOGLIOLO, G

PANNACCIULLI, I

机构：

来源：

ANNALS OF HEMATOLOGY | 1995年 / 71卷 / 03期

关键词：

HYDROXYUREA; HEMATOPOIETIC PROGENITOR CELLS; POLYCYTHEMIA VERA;

D O I：

10.1007/s002770050094

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The in vivo effects of hydroxyurea (HU) on circulating erythroid (BFU-E) and granulocyte-macrophage progenitors (CFU-GM) in patients with polycythemia vera (PV) have been evaluated, HU induced a strong decrease of both BFU-E and CFU-GM in the first month of treatment, During the following 4 months of treatment the level of circulating progenitors remained at very low values, until the end of the period of observation. HU activity involved both erythroid and myeloid committed progenitors and both erythropoietin-stimulated (normal) and endogenous (derived from the abnormal PV clone) BFU-E.

引用

页码：119 / 121

页数：3

共 13 条

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[2]

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[3]

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