GROWTH-HORMONE INCREASES THE MASS, THE COLLAGENOUS PROTEINS, AND THE STRENGTH OF RAT COLON

被引：18

作者：

CHRISTENSEN, H ^{[1
]}

JORGENSEN, PH ^{[1
]}

OXLUND, H ^{[1
]}

LAURBERG, S ^{[1
]}

机构：

[1] AARHUS UNIV,AARHUS KOMMUNE HOSP,INST EXPTL CLIN RES,DK-8000 AARHUS,DENMARK

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 25卷 / 11期

关键词：

Collagen; Colon; Growth; Growth hormone;

D O I：

10.3109/00365529008998546

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of growth hormone treatment on the left colon was investigated in 4-month-old Wistar rats. The animals were injected with saline (controls) or biosynthetic human growth hormone (b-hGH) in doses of 1.0 and 5.0 mg b-hGH/kg/day for 30 days. The total body weight of the rats injected with 1.0 mg b-hGH/kg/day did not differ from that of the control group, whereas the body weight of the rats injected with 5.0 mg b-hGH/kg/day was increased by 37% compared with the control group. The colonic dry weight per unit length was increased by 57% and 46% by 1.0 mg and 5.0 mg b-hGH/kg/day, respectively. The defatted dry weight was increased by 52% and 44% respectively. The hydroxyproline content per unit length was increased by 31% and 23% respectively. Furthermore, the biomechanical strength was increased by the b-hGH injections. No difference between the two b-hGH doses was found in any of the data. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1137 / 1143

页数：7

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