CENTRAL MUSCARINIC ACTIVITIES OF AN M1-SELECTIVE AGONIST - PREFERENTIAL EFFECT ON REVERSAL OF AMNESIA

被引：20

作者：

NAKAHARA, N ^{[1
]}

FUJISE, N ^{[1
]}

KAWANISHI, G ^{[1
]}

MIZOBE, F ^{[1
]}

机构：

[1] SNOW BRAND MILK PROD CO LTD,LIFE SCI RES INST,519 ISHIBASHI MACHI,TOCHIGI 32905,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 507卷 / 01期

关键词：

AF102B; FKS-508; Hypothermia; Muscarinic agonist; M1; Oxotremorine; Passive avoidance; Scopolamine; Tremor;

D O I：

10.1016/0006-8993(90)90541-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of FKS-508 (AF102B; cis-2-methylspiro (1,3-oxathiolane-5,3′)-quinuclide), a novel M1-selective agonist, on central muscarinic responses in mice were examined in comparison with oxotremorine. FKS-508 was slightly less potent (6 times) in reversal of scopolamine-induced amnesia (passive avoidance failure), but far less potent (260 and 55 times) in producing hypothermia and tremor than oxotremorine. These results show that the selective M1 agonist FKS-508 differentiates highly between the central muscarinic effects. © 1990.

引用

页码：172 / 175

页数：4

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