EFFECT OF LOW-LEVEL AND INTERMITTENT MINOCYCLINE THERAPY ON THE GROWTH OF MYCOBACTERIUM-LEPRAE IN MICE

被引:13
作者
GELBER, RH
SIU, P
TSANG, M
ALLEY, P
MURRAY, LP
机构
[1] Kuzell Institute for Arthritis, Medical Research Institute, San Francisco, CA 94115-1896
关键词
D O I
10.1128/AAC.35.5.992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We evaluated the minimal concentrations of minocycline in the diet and in serum required to inhibit the growth of seven Mycobacterium leprae isolates in mice. Minocycline concentrations of 0.01 and 0.04% in the diet, which resulted in levels in serum of less-than-or-equal-to 0.17 and 0.51-mu-g/ml, respectively, were consistently and completely inhibitory. Even 0.004% dietary minocycline (levels in serum, less-than-or-equal-to 0.08-mu-g/ml) partially inhibited five of these strains, while 0.001% minocycline was consistently inactive. For five of these isolates, minocycline at a concentration of 0.04% in the diet given 3 days (Monday, Wednesday, Friday) and 1 day weekly completely inhibited the growth of M. leprae, and minocycline given even 1 day monthly was partially inhibitory for three of these five M. leprae isolates.
引用
收藏
页码:992 / 994
页数:3
相关论文
共 16 条
[1]  
BAKER RJ, 1990, INT J LEPROSY, V58, P78
[2]  
BAOHONG J, 1987, International Journal of Leprosy and Other Mycobacterial Diseases, V55, P830
[3]  
GELBER R, 1990, 30TH INT C ANT AG CH
[4]  
Gelber R H, 1990, Prog Drug Res, V34, P421
[5]   ACTIVITY OF MINOCYCLINE IN MYCOBACTERIUM-LEPRAE INFECTED MICE [J].
GELBER, RH .
JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (01) :236-239
[6]  
GELBER RH, 1987, INT J LEPROSY, V55, P78
[7]  
GROSSET JH, 1988, INT J LEPROSY, V56, P259
[8]  
GUELPALAURAS CC, 1987, INT J LEPROSY, V55, P70
[9]  
MACDONALD H, 1973, CLIN PHARMACOL THER, V14, P852
[10]   ABSORPTION, DISTRIBUTION, METABOLIC-FATE, AND ELIMINATION OF PEFLOXACIN MESYLATE IN MICE, RATS, DOGS, MONKEYS, AND HUMANS [J].
MONTAY, G ;
GOUEFFON, Y ;
ROQUET, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (04) :463-472