EFFECTS OF THE ANGIOTENSIN-I CONVERTING-ENZYME-INHIBITOR PERINDOPRIL ON CEREBRAL BLOOD-FLOW IN AWAKE HYPERTENSIVE RATS

被引：12

作者：

BRAY, L ^{[1
]}

LARTAUD, I ^{[1
]}

MULLER, F ^{[1
]}

ATKINSON, J ^{[1
]}

CAPDEVILLE, C ^{[1
]}

机构：

[1] FAC PHARM NANCY,PHARMACOL CARDIOVASC LAB,5 RUE ALBERT LEBRUN,F-54000 NANCY,FRANCE

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 03期

关键词：

ANGIOTENSIN-I CONVERTING ENZYME INHIBITION; SPONTANEOUS HYPERTENSION; RENOVASCULAR HYPERTENSION; CEREBRAL BLOOD FLOW AUTOREGULATION;

D O I：

10.1093/ajh/4.3.246S

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

As chronic hypertension shifts the lower limit of cerebral blood flow (CBF) autoregulation to higher pressure levels, we studied the effects of the angiotensin converting enzyme (ACE) inhibitor, perindopril on mean arterial pressure (mean BP), basal CBF, and CBF autoregulation in awake renovascular hypertensive (2 kidneys, 1 clip model) and spontaneously hypertensive rats (SHR). Blood pressure was measured via a chronically implanted arterial cannula and CBF by hydrogen clearance. Chronic renovascular hypertension, like spontaneous hypertension, caused a marked shift in the lower limit of CBF autoregulation but did not alter basal CBF. In SHR, acute administration of perindopril did not diminish CBF in spite of the fact that BP fell to a level below the lower limit of CBF autoregulation (determined by hypotensive hemorrhage). Chronic treatment of renovascular hypertensive rats with perindopril normalized BP and restored CBF autoregulation.

引用

页码：S246 / S252

页数：7