AGE-DEPENDENCY OF INFECTION STATUS AND SERUM ANTIBODY-LEVELS IN HUMAN WHIPWORM (TRICHURIS-TRICHIURA) INFECTION

被引:33
作者
BUNDY, DAP
LILLYWHITE, JE
DIDIER, JM
SIMMONS, I
BIANCO, AE
机构
[1] UNIV CTR, PARASITE EPIDEMIOL PROJECT, CASTRIES, ST LUCIA
[2] MINIST HLTH, CASTRIES, ST LUCIA
基金
英国惠康基金;
关键词
TRICHURIS-TRICHIURA; AGE-DEPENDENT; ANTIBODY RESPONSE; INFECTION INTENSITY;
D O I
10.1111/j.1365-3024.1991.tb00558.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study examines the age-dependency of the relationships between human infection with whipworm (Trichuris trichiura) and parasite-specific antibody level measured by ELISA against an extract of adult worms after preincubation of the sera with Ascaris lumbricoides adult worm extract. The convex age-profile of parasite infection intensity is shown to be mirrored by an age-dependent change in age-class mean levels of IgG (all subclasses except IgG3), IgA, IgM and IgE. Mean antibody levels rise with increasing acquisition of infection in childhood and decline as the intensity of infection falls in adulthood. Immunoblot analysis of selected sera from different age-classes indicates that antigen recognition is similarly dependent on infection intensity. In individual children, antibody levels correlate positively with acquisition of infection, consistent with a simple model of antigen dosage specifying the magnitude of the humoral immune response. In adults, IgG4 correlates positively and IgA negatively with intensity of infection, suggesting involvement of these isotypes in functional roles of immune blockade or effector mechanisms, respectively.
引用
收藏
页码:629 / 638
页数:10
相关论文
共 26 条
[1]   POPULATION-DYNAMICS OF HUMAN HELMINTH INFECTIONS - CONTROL BY CHEMOTHERAPY [J].
ANDERSON, RM ;
MAY, RM .
NATURE, 1982, 297 (5867) :557-563
[3]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4]  
BRADLEY DJ, 1974, T ROY SOC TROP MED H, V80, P706
[6]   AGE-RELATED PREVALENCE AND INTENSITY OF TRICHURIS-TRICHIURA INFECTION IN A ST-LUCIAN COMMUNITY [J].
BUNDY, DAP ;
COOPER, ES ;
THOMPSON, DE ;
ANDERSON, RM ;
DIDIER, JM .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (01) :85-94
[8]  
BUNDY DAP, 1984, INT J ZOONOSES, V11, P1
[9]  
BUNDY DAP, 1989, ADV PARASIT, V28, P107
[10]   LONGITUDINAL-STUDIES ON HUMAN SCHISTOSOMIASIS [J].
BUTTERWORTH, AE ;
FULFORD, AJC ;
DUNNE, DW ;
OUMA, JH ;
STURROCK, RF .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1988, 321 (1207) :495-511