INTERLEUKIN-3 PROMOTES HISTAMINE SYNTHESIS IN HEMATOPOIETIC PROGENITORS BY INCREASING HISTIDINE-DECARBOXYLASE MESSENGER-RNA EXPRESSION

被引:34
作者
DY, M
MACHAVOINE, F
LEBEL, B
ICHIKAWA, A
GASTINEL, LN
SCHNEIDER, E
机构
[1] KYOTO UNIV,FAC PHARMACEUT SCI,KYOTO 606,JAPAN
[2] CALTECH,PASADENA,CA 91125
关键词
D O I
10.1006/bbrc.1993.1396
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interleukin 3 (IL-3) is a potent stimulator of histamine production by cells from murine hematopoietic organs. We demonstrate herein that this phenomenon results from increased histidine decarboxylase (HDC: EC 4.1.1.22) activity in progenitor-enriched bone marrow cells (around 5% of the total bone marrow) isolated from the low density layers of a discontinuous Ficoll gradient. HDC levels are markedly enhanced after a 24 h incubation with IL-3 while a 4 h exposure results only in a slight activation. It results from increased expression of the mRNA coding for HDC, as assessed by Northern blot analysis after a 24 h incubation with IL-3. At the same time point and after a 4 h stimulation, we have evaluated the percentage of cells in this population which express HDC mRNA in response to IL-3, using in situ hybridization with the antisense riboprobe. We have thus established that enhanced HDC mRNA expression occurs in a small immature subset representing from 5 to 8% of the progenitor-enriched bone marrow cells. © 1993 Academic Press, Inc.
引用
收藏
页码:167 / 173
页数:7
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