2 RAT HOMOLOGS OF CLATHRIN-ASSOCIATED ADAPTER PROTEINS

被引：67

作者：

PEVSNER, J ^{[1
]}

VOLKNANDT, W ^{[1
]}

WONG, BR ^{[1
]}

SCHELLER, RH ^{[1
]}

机构：

[1] STANFORD UNIV, SCH MED,BECKMAN CTR,HOWARD HUGHES MED INST, DEPT MOLEC & CELLULAR PHYS, STANFORD, CA 94305 USA

来源：

GENE | 1994年 / 146卷 / 02期

关键词：

ASSEMBLY PROTEINS; MEMBRANE TRAFFICKING; RECYCLING; VESICLES; RAY ELECTRIC LOBE;

D O I：

10.1016/0378-1119(94)90306-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A cDNA clone predicted to encode a 46 757-Da protein was isolated from a library derived from the electric lobe of the ray Discopyge ommata. Two rat homologs, p47A and p47B, were subsequently isolated. These three proteins share approx. 80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles. These complexes are involved in receptor-mediated pathways of intracellular transport. Rat p47A mRNA is expressed in all tissues examined, including brain, heart, kidney, liver, lung, muscle and spinal cord. Rat p47B mRNA is detected exclusively in brain and spinal cord, and may participate in nervous system-specific functions such as biogenesis or recycling of synaptic vesicles.

引用

页码：279 / 283

页数：5

共 31 条

[1] STRUCTURAL RELATIONSHIPS BETWEEN CLATHRIN ASSEMBLY PROTEINS FROM THE GOLGI AND THE PLASMA-MEMBRANE [J].