MECHANISMS OF MESSENGER-RNA DEGRADATION IN EUKARYOTES

被引：218

作者：

DECKER, CJ

PARKER, R

机构：

[1] C. J. Decker and R. Parker are, the Department of Molecular and Cellular Biology, University of Arizona, Tucson

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 08期

关键词：

D O I：

10.1016/0968-0004(94)90073-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent experiments have identified distinct mechanisms of eukaryotic RNA turnover. In one mechanism, deadenylation triggers decapping, exposing the messenger RNA to 5' to 3' degradation. This pathway may act at different rates on the majority of messenger RNAs. There are also degradation mechanisms, such as endonucleolytic cleavage, limited to messenger RNAs containing specific sequence elements.

引用

页码：336 / 340

页数：5

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