FOVEAL THICKENING IN RETINITIS-PIGMENTOSA PATIENTS WITH CYSTOID MACULAR EDEMA

被引：21

作者：

SHAHIDI, M

FISHMAN, G

OGURA, Y

AMBROZ, K

ZEIMER, R

机构：

[1] Department of Ophthalmology and Visual Sciences, UIC Eye Center, University of Illinois at Chicago, Chicago, IL

[2] Department of Ophthalmology, Kyoto University, Kyoto

[3] Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1994年 / 14卷 / 03期

关键词：

FOVEAL THICKENING; CYSTOID MACULAR EDEMA; FLUORESCEIN LEAKAGE; METHAZOLAMIDE TREATMENT; RETINITIS PIGMENTOSA;

D O I：

10.1097/00006982-199414030-00009

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: Clinical evaluation of cystoid macular edema (CME), known to occur in patients with retinitis pigmentosa (RP), is based on the presence of vascular leakage on fluorescein angiography. Due to an inability to quantitatively assess retinal thickening, the degree of thickening from fluid accumulation and its relation to fluorescein dye leakage into the extravascular retinal space has not been established. The relationship between fluorescein dye leakage and foveal thickening and the effect of methazolamide treatment was studied. Methods: The retinal thickness analyzer was used to measure the degree of thickening in six patients with RP and CME. A laser beam was projected at an oblique angle to the retina, and images of the intersection of the laser slit with the anterior and posterior retinal surfaces were recorded. The digitized images were analyzed using a dedicated software program to provide quantitative measurements of retinal thickness. Routine fluorescein angiography was performed. Results: The amount of fluorescein dye leakage was not indicative of the degree of retinal thickening due to fluid accumulation. Foveal thickening and fluorescein dye leakage were reduced in five of six eyes after methazolamide treatment. Eyes with moderate thickening reversed to normal, whereas eyes with severe thickening showed only a minimal reduction in thickness. Concusion: Retinal thickness measurement is a useful method of evaluating both the extent of and changes in retinal thickness after carbonic anhydrase treatment.

引用

页码：243 / 247

页数：5

共 13 条

[1] Ffytche T.J., Cystoid maculopathy in retinitis pigmentosa, Eye, 92, pp. 265-283, (1972)
[2] Fetkenhour C.L., Choromokos E., Weinstein J., Shoch D., Cystoid macular edema in retinitis pigmentosa, Ophthalmology, 83, pp. 515-521, (1977)
[3] Newsome D.A., Retinal fluorescein leakage in retinitis pigmentosa, Am J Ophthalmol, 101, pp. 354-360, (1986)
[4] Spallone A., Retinal fluorescein leakage in retinitis pigmentosa, Am J Ophthalmol, 102, (1986)
[5] Cox S.N., Hay E., Bird A.C., Treatment of chronic macular edema with acetazolamide, Arch Ophthalmol, 106, pp. 1190-1195, (1988)
[6] Fishman G.A., Gilbert L.D., Fiscella R.G., Et al., Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa, Arch Ophthalmol, 107, pp. 1445-1452, (1989)
[7] Newsome D.A., Blacharski P.A., Grid photocoagulation for macular edema in patients with retinitis pigmentosa, Am J Ophthalmol, 103, pp. 161-166, (1987)
[8] Zeimer R.C., Shahidi M., Mori M.T., Benhamou E., In vivo evaluation of a noninvasive method to measure the retinal thickness in primates, Arch Ophthalmol, 107, pp. 1006-1009, (1989)
[9] Shahidi M., Zeimer R.C., Mori M., Topography of the retinal thickness in normal subjects, Ophthalmology, 97, pp. 1120-1124, (1990)
[10] Miyake K., Prevention of cystoid macular edema after lens extraction by topical indomethacin, I. A Preliminary Report. Graefes Arch Clin Exp Ophthalmol, 203, pp. 81-88, (1977)

← 1 2 →