RETRACTED: Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin (Retracted article. See vol. 12, pg. 1, 2019)

被引:72
作者
Akbarzadeh, Abolfazl [1 ]
Zarghami, Nosratollah [2 ]
Mikaeili, Haleh [3 ]
Asgari, Davoud [4 ]
Goganian, Amir Mohammad [5 ]
Khiabani, Hanie Khaksar [5 ]
Samiei, Mohammad [6 ]
Davaran, Soodabeh [3 ]
机构
[1] Tabriz Univ Med Sci, Dept Med Chem, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Med, Dept Clin Biochem & Lab Med, Div Med Biotechnol, Tabriz, Iran
[3] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[5] Univ Tabriz, Fac Chem, Dept Organ Chem, Tabriz, Iran
[6] Tabriz Univ Med Sci, Fac Dent, Tabriz, Iran
基金
美国国家科学基金会;
关键词
magnetic nanoparticles; drug loading; doxorubicin release; biocompatibility;
D O I
10.2147/NSA.S24328
中图分类号
TB3 [工程材料学];
学科分类号
0805 [材料科学与工程]; 080502 [材料学];
摘要
Poly (N-isopropylacrylamide-methyl methacrylic acid, PNIPAAm-MAA)-grafted magnetic nanoparticles were synthesized using silane-coated magnetic nanoparticles as a template for radical polymerization of N-isopropylacrylamide and methacrylic acid. Properties of these nanoparticles, such as size, drug-loading efficiency, and drug release kinetics, were evaluated in vitro for targeted and controlled drug delivery. The resulting nanoparticles had a diameter of 100 nm and a doxorubicin-loading efficiency of 75%, significantly higher doxorubicin release at 40 degrees C compared with 37 degrees C, and pH 5.8 compared with pH 7.4, demonstrating their temperature and pH sensitivity, respectively. In addition, the particles were characterized by X-ray powder diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. In vitro cytotoxicity testing showed that the PNIPAAm-MAA-coated magnetic nanoparticles had no cytotoxicity and were biocompatible, indicating their potential for biomedical application.
引用
收藏
页码:13 / 25
页数:13
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