RETRACTED: Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin (Retracted article. See vol. 12, pg. 1, 2019)

被引：72

作者：

Akbarzadeh, Abolfazl ^{[1
]}

Zarghami, Nosratollah ^{[2
]}

Mikaeili, Haleh ^{[3
]}

Asgari, Davoud ^{[4
]}

Goganian, Amir Mohammad ^{[5
]}

Khiabani, Hanie Khaksar ^{[5
]}

Samiei, Mohammad ^{[6
]}

Davaran, Soodabeh ^{[3
]}

机构：

[1] Tabriz Univ Med Sci, Dept Med Chem, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Med, Dept Clin Biochem & Lab Med, Div Med Biotechnol, Tabriz, Iran

[3] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[5] Univ Tabriz, Fac Chem, Dept Organ Chem, Tabriz, Iran

[6] Tabriz Univ Med Sci, Fac Dent, Tabriz, Iran

来源：

NANOTECHNOLOGY SCIENCE AND APPLICATIONS | 2012年 / 5卷

基金：

美国国家科学基金会;

关键词：

magnetic nanoparticles; drug loading; doxorubicin release; biocompatibility;

D O I：

10.2147/NSA.S24328

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 [材料科学与工程]; 080502 [材料学];

摘要：

Poly (N-isopropylacrylamide-methyl methacrylic acid, PNIPAAm-MAA)-grafted magnetic nanoparticles were synthesized using silane-coated magnetic nanoparticles as a template for radical polymerization of N-isopropylacrylamide and methacrylic acid. Properties of these nanoparticles, such as size, drug-loading efficiency, and drug release kinetics, were evaluated in vitro for targeted and controlled drug delivery. The resulting nanoparticles had a diameter of 100 nm and a doxorubicin-loading efficiency of 75%, significantly higher doxorubicin release at 40 degrees C compared with 37 degrees C, and pH 5.8 compared with pH 7.4, demonstrating their temperature and pH sensitivity, respectively. In addition, the particles were characterized by X-ray powder diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. In vitro cytotoxicity testing showed that the PNIPAAm-MAA-coated magnetic nanoparticles had no cytotoxicity and were biocompatible, indicating their potential for biomedical application.

引用

页码：13 / 25

页数：13

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