MURINE INTERLEUKIN-2 RECEPTOR BETA-CHAIN - DYSREGULATED GENE-EXPRESSION IN LYMPHOMA LINE EL-4 CAUSED BY A PROMOTER INSERTION

被引：106

作者：

KONO, T

DOI, T

YAMADA, G

HATAKEYAMA, M

MINAMOTO, S

TSUDO, M

MIYASAKA, M

MIYATA, T

TANIGUCHI, T

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

[2] KYUSHU UNIV,FAC SCI,DEPT BIOL,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 05期

关键词：

D O I：

10.1073/pnas.87.5.1806

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The functional, high-affinity interleukin 2 receptor (IL-2R) consists of at least two receptor components, IL-2Rα (p55) and IL-2Rβ (p70-75). The cDNA encoding the murine IL-2Rβ has been ed by using the previously cloned cDNA for human IL-2Rβ as a probe. Analysis of the cDNA revealed that the murine IL-2Rβ shows a marked homology with the human IL-2Rβ and that it is also structurally related to other cytokine receptors such as erythropoietin receptor. The cDNA-directed murine IL-2Rβ formed high-affinity IL-2R in conjunction with the endogenous IL-2Rα in a murine pro-B-cell line and could transduce IL-2-induced growth signal. In mouse lymphoma line EL-4, the IL-2Rβ gene was found to be rearranged by the insertion of the long terminal repeat sequence of an intracisternal A particle, giving rise to constitutive expression of the IL-2Rβ mRNA.

引用

页码：1806 / 1810

页数：5

共 40 条

[1] ALLOUCHE M, 1989, J IMMUNOL, V143, P2223
[2] A NOVEL FAMILY OF GROWTH-FACTOR RECEPTORS - A COMMON BINDING DOMAIN IN THE GROWTH-HORMONE, PROLACTIN, ERYTHROPOIETIN AND IL-6 RECEPTORS, AND THE P75 IL-2 RECEPTOR BETA-CHAIN
BAZAN, JF
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (02) : 788 - 795
[3] REARRANGEMENT OF THE ONCOGENE C-MOS IN MOUSE MYELOMA NSI AND HYBRIDOMAS
COHEN, JB
UNGER, T
RECHAVI, G
CANAANI, E
GIVOL, D
[J]. NATURE, 1983, 306 (5945) : 797 - 799
[4] TRANSFER OF FUNCTIONAL EGF RECEPTORS TO AN IL3-DEPENDENT CELL-LINE
COLLINS, MKL
DOWNWARD, J
MIYAJIMA, A
MARUYAMA, K
ARAI, KI
MULLIGAN, RC
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1988, 137 (02) : 293 - 298
[5] ERYTHROPOIETIN RECEPTOR AND INTERLEUKIN-2 RECEPTOR BETA-CHAIN - A NEW RECEPTOR FAMILY
DANDREA, A
FASMAN, GD
LODISH, HF
[J]. CELL, 1989, 58 (06) : 1023 - 1024
[6] EXPRESSION CLONING OF THE MURINE ERYTHROPOIETIN RECEPTOR
DANDREA, AD
LODISH, HF
WONG, GG
[J]. CELL, 1989, 57 (02) : 277 - 285
[7] Dayhoff MO, 1978, ATL PROTEIN SEQ STRU, V5, P345
[8] DOI T, 1989, EMBO J, V8, P1953, DOI 10.1002/j.1460-2075.1989.tb03600.x
[9] A 2ND HUMAN INTERLEUKIN-2 BINDING-PROTEIN THAT MAY BE A COMPONENT OF HIGH-AFFINITY INTERLEUKIN-2 RECEPTORS
DUKOVICH, M
WANO, Y
THUY, LTB
KATZ, P
CULLENS, BR
KEHRL, JH
GREENE, WC
[J]. NATURE, 1987, 327 (6122) : 518 - 522
[10] REGULATION OF HUMAN INTERLEUKIN-2 GENE - FUNCTIONAL DNA-SEQUENCES IN THE 5' FLANKING REGION FOR THE GENE-EXPRESSION IN ACTIVATED LYMPHOCYTES-T
FUJITA, T
SHIBUYA, H
OHASHI, T
YAMANISHI, K
TANIGUCHI, T
[J]. CELL, 1986, 46 (03) : 401 - 407

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