CONCURRENT HYPERCORTISOLISM AND HYPERALDOSTERONISM DUE TO AN ADRENAL ADENOMA

被引：11

作者：

HOBMA, S ^{[1
]}

HERMUS, A ^{[1
]}

PIETERS, G ^{[1
]}

SMALS, A ^{[1
]}

KLOPPENBORG, P ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,ST RADBOUD HOSP,DEPT MED,DIV ENDOCRINOL,GEERT GROTEPLEIN ZUID 8,6525 GA NIJMEGEN,NETHERLANDS

来源：

KLINISCHE WOCHENSCHRIFT | 1990年 / 68卷 / 19期

关键词：

Adrenal adenoma; Hyperaldosteronism; Hypercortisolism;

D O I：

10.1007/BF01646658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The case of a 39-year-old woman with Cushing's syndrome, hypertension and severe hypokalemia, caused by a unilateral adrenal adenoma composed of cells of the zona fasciculata histological type, is described. Plasma renin activity, plasma levels of mineralocorticoids and the aldosterone secretion rate were determined before and after surgical removal of the adenoma. The tumor appeared to produce autonomously cortisol as well as corticosterone, 18-hydroxycorticosterone and aldosterone. This condition has not previously been described in the literature and might be explained by strong expression of the full spectrum of activities of the mitochondrial enzyme P450 C11 by the tumor cells. Interestingly, despite hyperaldosteronism, plasma renin activity was not suppressed. © 1990 Springer-Verlag.

引用

页码：981 / 983

页数：3

共 16 条

[1] DEOXYCORTICOSTERONE AND ALDOSTERONE EXCRETION IN CUSHINGS-SYNDROME [J].