THE CHIRAL SYNTHESIS OF THIAZOLE AMINO-ACID ENANTIOMERS

被引:105
作者
BREDENKAMP, MW
HOLZAPFEL, CW
VANZYL, WJ
机构
[1] Department of Chemistry and Biochemistry, Rand Afrikaans University, JOHANNESBURG, 2000
关键词
D O I
10.1080/00397919008053164
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient modified Hantzsch reaction is described for the synthesis of optically pure thiazole amino acid derivatives from the corresponding amino acids. The method is exemplified by the synthesis of a derivative of L-(Gln)Thz, the novel chiral thiazole amino acid moiety of dolastatin 3, The Cotton effects of thiazole amino acids correlate well with the absolute stereochemistry of these compounds. © 1990, Taylor & Francis Group, LLC. All rights reserved.
引用
收藏
页码:2235 / 2249
页数:15
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