INHIBITION OF STEROL BUT NOT FATTY-ACID SYNTHESIS BY VALPROATE IN DEVELOPING RAT-BRAIN INVIVO

被引：7

作者：

BOLANOS, JP ^{[1
]}

MEDINA, JM ^{[1
]}

WILLIAMSON, DH ^{[1
]}

机构：

[1] RADCLIFFE INFIRM,NUFFIELD DEPT CLIN MED,METAB RES LAB,WOODSTOCK RD,OXFORD OX2 6HE,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1990年 / 272卷 / 01期

关键词：

D O I：

10.1042/bj2720251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of administration of valproate on lipogenesis in the developing rat brain in vivo was studied. Valproate inhibited by 21-38% the rate of 3H2O incorporation into brain sterols, without significantly affecting fatty acid synthesis. Similarly, R-[2-14C]mevalonate incorporation into sterols was inhibited by 33-54%; the low rate of fatty acid synthesis under these conditions was not affected by valproate. Plasma ketone bodies decreased after treatment with valproate. Valproate inhibited (about 50%) both sterol and fatty acid synthesis in livers of weanling rats. It is concluded that valproate can specifically inhibit sterol synthesis in the brain during development, in part at a stage after mevalonate formation, and also by decreased exogenous precursor supply.

引用

页码：251 / 253

页数：3