IMMUNOLOGICAL MARKERS IN THE CEREBROSPINAL-FLUID OF HIV-1-INFECTED CHILDREN

被引：36

作者：

GALLO, P

LAVERDA, AM

DEROSSI, A

PAGNI, S

DELMISTRO, A

COGO, P

PICCINNO, MG

PLEBANI, A

TAVOLATO, B

CHIECOBIANCHI, L

机构：

[1] INTERUNIV CTR RES CANC,DEPT ONCOL,PADUA,ITALY

[2] INTERUNIV CTR RES CANC,INST NEUROL,PADUA,ITALY

[3] UNIV PADUA,DEPT PAEDIATR,PADUA,ITALY

[4] CLIN PAEDIAT DEMARCHI,MILAN,ITALY

来源：

ACTA PAEDIATRICA SCANDINAVICA | 1991年 / 80卷 / 6-7期

关键词：

HIV-1; CEREBROSPINAL FLUID; CHILDREN; CYTOKINES;

D O I：

10.1111/j.1651-2227.1991.tb11926.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Several immunological abnormalities were detected in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected children. Intrathecal synthesis of immunoglobulins, free light chains (FLC), IL-1-beta, IL-6, and M-CSF were demonstrated both in asymptomatic children and children with subacute encephalopathy. Our findings further support the hypothesis that an immunopathological subclinical process within the central nervous system (CNS) may be an early manifestation of acquired immunodeficiency syndrome (AIDS). Cytokine detection in the CSF may represent a useful diagnostic tool in evaluating the outcome of HIV-1-infected patients.

引用

页码：659 / 666

页数：8

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