STABILIZATION OF ASPARTAME BY CYCLODEXTRINS

被引：6

作者：

BREWSTER, ME

LOFTSSON, T

BALDVINSDOTTIR, J

BODOR, N

机构：

[1] UNIV ICELAND,DEPT PHARM,IS-101 REYKJAVIK,ICELAND

[2] PHARMATEC INC,ALACHUA,FL

[3] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,CTR DRUG DISCOVERY,GAINESVILLE,FL 32610

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 75卷 / 01期

关键词：

ASPARTAME; STABILIZATION; BETA-CYCLODEXTRIN DERIVATIVE; AQUEOUS SOLUTION;

D O I：

10.1016/0378-5173(91)90257-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The primary and secondary hydroxyl groups on the beta-cyclodextrin molecule were selectively substituted by 2-hydroxypropyl ether groups. The influence of 2-hydroxypropyl-beta-cyclodextrin, substituted mainly at the primary or the secondary hydroxyl groups, on the hydrolysis rate of aspartame was investigated and compared to the effects of 2-hydroxypropyl-beta-cyclodextrin (Encapsin (TM) from Janssen, a mixture of maltosyl- and dimaltosyl-beta-cyclodextrin, and 2-hydroxyethyl-beta-cyclodextrin. All the cyclodextrin derivatives decreased the rate of hydrolysis of aspartame in solution. The distribution of the 2-hydroxypropyl substituent on the beta-cyclodextrin molecule affected its stabilizing effect.

引用

页码：R5 / R8

页数：4

共 8 条

[1]

LOFTSSON T, 1990, ACTA PHARM NORDICA, V2, P303

[2]

Loftsson T., 1991, PHARM ZTG WISS, V4, P5

[3] HYDROXYPROPYL-BETA-CYCLODEXTRIN - PREPARATION AND CHARACTERIZATION - EFFECTS ON SOLUBILITY OF DRUGS [J].