CORTICOSTEROIDOGENESIS BY ISOLATED HUMAN ADRENAL-CELLS - EFFECT OF SEROTONIN AND SEROTONIN ANTAGONISTS

被引：17

作者：

RACZ, K

WOLF, I

KISS, R

LADA, G

VIDA, S

GLAZ, E

机构：

[1] 2nd Department of Medicine, Semmelweis University, School of Medicine, Budapest

来源：

EXPERIENTIA | 1979年 / 35卷 / 11期

关键词：

D O I：

10.1007/BF01962830

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid-particularly cortisol and aldosterone-biosynthesis. © 1979 Birkhäuser Verlag.

引用

页码：1532 / 1534

页数：3

共 14 条

[1] STEROIDOGENESIS IN ISOLATED RAT ADRENAL GLOMERULOSA CELLS - RESPONSE TO PHYSIOLOGICAL CONCENTRATIONS OF ANGIOTENSIN-II AND EFFECTS OF POTASSIUM, SEROTONIN AND [SAR1,ALA8]-ANGIOTENSIN-II
BING, RF
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[2] ALDOSTERONE DIAGNOSIS IN HYPERTENSION - COMPARATIVE EVALUATION OF RADIOIMMUNOASSAYS FOR URINARY ALDOSTERONE AND CORTICOSTERONE-18-OH
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AMMENTI, A
[J]. KLINISCHE WOCHENSCHRIFT, 1978, 56 : 173 - 181
[3] STUDIES ON ISOLATED RAT ADRENAL-CELLS .1. CONTINUOUS-FLOW AND BATCH INCUBATIONS
FALKE, HE
DEGENHART, HJ
ABELN, GJA
VISSER, HKA
CROUGHS, RJM
[J]. ACTA ENDOCRINOLOGICA, 1975, 78 (01): : 110 - 121
[4] GLAZ E, 1979, PATHOMECHANISM CLIN, P43
[5] GLAZ E, 1971, ALDOSTERONE, P377
[6] KRAIEM Z, 1978, J STEROID BIOCH, V9
[7] Krieger D T, 1977, Ann N Y Acad Sci, V297, P527, DOI 10.1111/j.1749-6632.1977.tb41880.x
[8] MULLER J, 1971, REGULATION ALDOSTERO, V5, P32
[9] MULLER J, 1979, PATHOMECHANISM CLIN, P21
[10] SWALLOW RL, 1969, P SOC EXP BIOL MED, V131, P1

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