PRODUCTION OF 12-HYDROXYEICOSATETRAENOIC ACID IN EARLY PREGNANT UTERINE CERVIX-LACK OF CORRELATION TO MIFEPRISTONE-INDUCED CERVICAL RIPENING - A DOUBLE-BLIND RANDOMIZED BIOMECHANICAL AND BIOCHEMICAL-STUDY

被引：6

作者：

HEIDVALL, K ^{[1
]}

RADESTAD, A ^{[1
]}

CHRISTENSEN, NJ ^{[1
]}

LINDGREN, JA ^{[1
]}

机构：

[1] KAROLINSKA HOSP,DEPT OBSTET & GYNAECOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

PROSTAGLANDINS | 1992年 / 43卷 / 05期

关键词：

D O I：

10.1016/0090-6980(92)90129-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of cervical ripening in pregnancy may involve arachidonic acid metabolites. We studied the formation of lipoxygenase products in cervical biopsies from twenty nulliparous women requesting a first trimester abortion. The patients were randomly allocated to receive either 100 mg of the progesterone antagonist mifepristone (RU 486) or placebo 48 and 36 hours before surgery. A capacity to produce significant amounts of 12-HETE and material co-chromatographing with leukotrienes was observed in the cervical tissue. No qualitative or quantitative relationship to mifepristone-induced cervical ripening was found. Although our data suggest a large variation of 12-HETE production it remains to clarify its role in the cervix.

引用

页码：473 / 482

页数：10

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