STRETCH-INDUCED INCREASE OF RESTING INTRACELLULAR CALCIUM-CONCENTRATION IN SINGLE GUINEA-PIG VENTRICULAR MYOCYTES

被引：66

作者：

LEGUENNEC, JY ^{[1
]}

WHITE, E ^{[1
]}

GANNIER, F ^{[1
]}

ARGIBAY, JA ^{[1
]}

GARNIER, D ^{[1
]}

机构：

[1] UNIV TOURS,FAC SCI,ELECTROPHYSIOL & PHARMACOL CELLULAIRES LAB,PARC GRANDMONT,F-37200 TOURS,FRANCE

来源：

EXPERIMENTAL PHYSIOLOGY | 1991年 / 76卷 / 06期

关键词：

D O I：

10.1113/expphysiol.1991.sp003560

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Single guinea-pig ventricular myocytes were loaded with the fluorescent Ca2+ indicator Indo-1 AM and stretched by carbon fibres. Stretching increased resting tension. Sarcomere lengths were increased by 2-18%. It was observed that a stretch increased resting [Ca2+]i in seven out of eight cells. The change in [Ca2+]i increased with the size of the stretch and returned to pre-stretch levels on return to resting cell length. These observations suggest a means by which changes in resting muscle length can modify the contractile state of cardiac muscle.

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页码：975 / 978

页数：4

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