ELEVATED BLOOD-PRESSURE AND CRANIOFACIAL ABNORMALITIES IN MICE DEFICIENT IN ENDOTHELIN-1

被引：851

作者：

KURIHARA, Y

KURIHARA, H

SUZUKI, H

KODAMA, T

MAEMURA, K

NAGAI, R

ODA, H

KUWAKI, T

CAO, WH

KAMADA, N

JISHAGE, K

OUCHI, Y

AZUMA, S

TOYODA, Y

ISHIKAWA, T

KUMADA, M

YAZAKI, Y

机构：

[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 3, BUNKYO KU, TOKYO 113, JAPAN

[2] UNIV TOKYO, FAC MED, DEPT PATHOL, BUNKYO KU, TOKYO 113, JAPAN

[3] UNIV TOKYO, FAC MED, DEPT PHYSIOL, BUNKYO KU, TOKYO 113, JAPAN

[4] UNIV TOKYO, FAC MED, DEPT GERIATR, BUNKYO KU, TOKYO 113, JAPAN

[5] CHUGAI PHARMACEUT CO LTD, GOTEMBA, SHIZUOKA 412, JAPAN

[6] UNIV TOKYO, INST MED SCI, DEPT REPROD & DEV BIOL, MINATO KU, TOKYO 108, JAPAN

来源：

NATURE | 1994年 / 368卷 / 6473期

关键词：

D O I：

10.1038/368703a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The endothelin-l (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These: ET-1(-/-) homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1(+/-) heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.

引用

页码：703 / 710

页数：8

共 47 条

[1] THE HUMAN HOX GENE FAMILY
ACAMPORA, D
DESPOSITO, M
FAIELLA, A
PANNESE, M
MIGLIACCIO, E
MORELLI, F
STORNAIUOLO, A
NIGRO, V
SIMEONE, A
BONCINELLI, E
[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (24) : 10385 - 10402
[2] [Anonymous], IN SITU HYBRIDIZATIO
[3] AZUMA S, 1991, Japanese Journal of Animal Reproduction, V37, P37
[4] BLOCH KD, 1989, J BIOL CHEM, V264, P10851
[5] ACTION OF ENDOTHELIN-1 ON VASOMOTOR NEURONS IN RAT ROSTRAL VENTROLATERAL MEDULLA
CAO, WH
KUWAKI, T
UNEKAWA, M
LING, GY
TERUI, N
KUMADA, M
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 22 : S196 - S198
[6] DEVELOPMENTAL DEFECTS OF THE EAR, CRANIAL NERVES AND HINDBRAIN RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.6
CHISAKA, O
MUSCI, TS
CAPECCHI, MR
[J]. NATURE, 1992, 355 (6360) : 516 - 520
[7] REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5
CHISAKA, O
CAPECCHI, MR
[J]. NATURE, 1991, 350 (6318) : 473 - 479
[8] DENUCCI G, 1988, P NATL ACAD SCI USA, V85, P9797
[9] ENDOTHELIN IS A POTENT SECRETAGOGUE FOR ATRIAL NATRIURETIC PEPTIDE IN CULTURED RAT ATRIAL MYOCYTES
FUKUDA, Y
HIRATA, Y
YOSHIMI, H
KOJIMA, T
KOBAYASHI, Y
YANAGISAWA, M
MASAKI, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (01) : 167 - 172
[10] ENDOTHELIN-1, AN ENDOTHELIUM-DERIVED PEPTIDE, IS EXPRESSED IN NEURONS OF THE HUMAN SPINAL-CORD AND DORSAL-ROOT GANGLIA
GIAID, A
GIBSON, SJ
IBRAHIM, NBN
LEGON, S
BLOOM, SR
YANAGISAWA, M
MASAKI, T
VARNDELL, IM
POLAK, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) : 7634 - 7638

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