REVERSAL OF SCOPOLAMINE-INDUCED AMNESIA BY THE GABA(B) RECEPTOR ANTAGONIST CGP-35348 IN THE MOUSE

被引：25

作者：

BIANCHI, M

PANERAI, AE

机构：

[1] Department of Pharmacology, University of Milano, Milan

来源：

COGNITIVE BRAIN RESEARCH | 1993年 / 1卷 / 02期

关键词：

GABA(B) RECEPTOR; CGP-35348; MEMORY; PASSIVE AVOIDANCE; SCOPOLAMINE-INDUCED AMNESIA;

D O I：

10.1016/0926-6410(93)90018-Z

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

We studied the effects of CGP 35348, a centrally active blocker of GABA(B) receptors, on scopolamine-induced amnesia for a passive avoidance response in the mouse. Both pre-training or post-training intraperitoneal administration of the GABA(B) antagonist (75, 150 and 300 mg/kg i.p.) significantly reduces the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results are in agreement with previous observations indicating a role for the GABA(B) receptors in the modulation of memory function, and suggest a possible role of GABA(B) receptor antagonists as nootropic drugs.

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页码：135 / 136

页数：2

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