EXTRACELLULAR DOPAMINE LEVELS WITHIN THE STRIATUM INCREASE DURING INHALATION EXPOSURE TO TOLUENE - A MICRODIALYSIS STUDY IN AWAKE, FREELY MOVING RATS

被引：42

作者：

STENGARD, K

HOGLUND, G

UNGERSTEDT, U

机构：

[1] NATL INST OCCUPAT HLTH,DEPT NEUROMED,S-17184 SOLNA,SWEDEN

[2] NATL INST OCCUPAT HLTH,DIV NEUROMED,S-17184 SOLNA,SWEDEN

来源：

TOXICOLOGY LETTERS | 1994年 / 71卷 / 03期

关键词：

ORGANIC SOLVENT; TOLUENE; EXTRACELLULAR DOPAMINE; MICRODIALYSIS;

D O I：

10.1016/0378-4274(94)90111-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

An exposure chamber for microdialysis on awake, freely moving rats during exposure to volatile agents is described. Inhalation exposure to 1000 and 2000 ppm toluene for 2 h was accompanied by an increase in extracellular dopamine levels within the striatum, but did not affect the homovanillic acid level. Neither the dopamine nor the homovanillic acid level was affected by toluene 500 ppm or isoamylacetate. It is suggested that the action of inhaled toluene on the dopamine neuron differs from that of the anaesthetic halothane, possibly by interfering with dopamine reuptake. Microdialysis seems to be a useful tool for studying the effects of volatile agents on brain neurotransmission.

引用

页码：245 / 255

页数：11

共 31 条

[1] TOLUENE-INDUCED ACTIVATION OF CERTAIN HYPOTHALAMIC AND MEDIAN-EMINENCE CATECHOLAMINE NERVE-TERMINAL SYSTEMS OF THE MALE-RAT AND ITS EFFECTS ON ANTERIOR-PITUITARY HORMONE-SECRETION [J].