DNA CLEAVAGE BY 4-ALKYNYL-3-METHOXY-4-HYDROXYCYCLOBUTENONE

被引：46

作者：

SULLIVAN, RW ^{[1
]}

COGHLAN, VM ^{[1
]}

MUNK, SA ^{[1
]}

REED, MW ^{[1
]}

MOORE, HW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 09期

关键词：

D O I：

10.1021/jo00088a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Alkynyl-3-methoxy-4-hydroxycyclobutenones, a readily available class of compounds, cleave supercoiled DNA by a mechanism that appears to require at least some involvement of diradical intermediates formed in the ring expansion of the cyclobutenones.

引用

页码：2276 / 2278

页数：3

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