SYNTHESIS OF A NOVEL SERIES OF 3-OXO-2,4-DIOXOBICYCLO[3.2.1]OCTANES - ADDITIONAL EVIDENCE FOR 2 THROMBOXANE RECEPTOR SUBTYPES

被引：4

作者：

BURK, RM ^{[1
]}

GAC, TS ^{[1
]}

GARST, ME ^{[1
]}

GIBSON, LL ^{[1
]}

KRAUSS, AH ^{[1
]}

PROTZMAN, CE ^{[1
]}

WOODWARD, DF ^{[1
]}

机构：

[1] ALLERGAN PHARMACEUT INC,DEPT BIOL SCI,IRVINE,CA 92713

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)80110-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series oa 3-oxo-2,4-dioxobicyclo[octanes(1-4) was synthesized and identified as potent thromboxane (TXA(2)) receptor aagonists. Replacement of the terminal -COOH group resulted in an unexpected change in biological activity: platelet aggregation, which typically occurs in response to TP-receptor stimulation, did not occur although potent contractile properties on vascular smooth muscle were retained.

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页码：2103 / 2106

页数：4

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