CONTINUOUS MEASUREMENT OF LEFT-VENTRICULAR VOLUME IN RABBIT, USING A 2-ELECTRODE CATHETER

被引：7

作者：

ABE, S ^{[1
]}

OHTOMO, J ^{[1
]}

YAMAGUCHI, I ^{[1
]}

TSUCHIDA, E ^{[1
]}

FUJINUMA, T ^{[1
]}

SUNAGAWA, K ^{[1
]}

TOMOIKE, H ^{[1
]}

机构：

[1] YAMAGATA UNIV,SCH MED,DEPT INTERNAL MED 1,YAMAGATA 99023,JAPAN

来源：

HEART AND VESSELS | 1995年 / 10卷 / 03期

关键词：

LEFT VENTRICULAR VOLUME; PRESSURE-VOLUME RELATION; 2-ELECTRODE CONDUCTANCE CATHETER; RABBIT;

D O I：

10.1007/BF01744480

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We developed a device for monitoring instantaneous left ventricular (LV) volume using an alternating-current excitation conductance catheter. Instantaneous between a pair of electrodes was amplified by a noninverting circuit. The level of conductance was linearly related to changes in blood volume from 0.8 to 2.0 ml in a latex balloon (r(2) = 0.95), and to changes in blood volume from 0.4 to 2.2 ml in a post-mortem rabbit left ventricle (r(2) = 0.99). The difference between the maximal and minimal conductance of the LV in situ during a cardiac cycle was closely correlated with changes in stroke volume, measured by an electromagnetic flow probe (r(2) = 0.97). The end-systolic pressure-conductance relation (ESPCR) was highly linear (r(2) = 0.92). Changes of the slope (Ees) of the ESPCR correlated directionally with changes of the time derivative of LV pressure (LVdP/dt) during intravenous infusions of dobutamine and propranolol. Accordingly, the two-electrode conductance catheter was useful in vivo in rabbits for continuously assessing changes in the LV volume.

引用

页码：138 / 145

页数：8

共 20 条

[1] Maughan W.L., Sunagawa K., Burkhoff D., Sagawa K., Effect of arterial impedance changes on the endsystolic pressure-volume relation, Circ Res, 54, pp. 595-602, (1984)
[2] Sagawa K., The ventricular pressure-volume diagram revisited, Circ Res, 43, pp. 677-687, (1978)
[3] Suga H., Sagawa K., Shoukas A.A., Load independence of the instantaneous pressure-volume ratio of the left ventricle and effect of epinephrine and heart rate on the ratio, Circ Res, 32, pp. 314-322, (1973)
[4] Baan J., Aouw Jong T.T., Kerkhof P.L.M., Moene R.J., Van Dijk A.D., Van der Velde E.T., Koops J., Continuous stroke volume and cardiac output from intraventricular dimensions obtained with impedance catheter, Cardiovasc Res, 15, pp. 328-334, (1981)
[5] Baan J., Van der Velde E.T., De Bruin H.G., Smeenk G.J., Koops J., Van Dijk A.D., Temmerman D., Senden J., Buis B., Continuous measurement of left ventricular volume in animals and humans by conductance catheter, Circulation, 70, pp. 812-823, (1984)
[6] Burkhoff D., Van der Velde E.T., Kass D., Baan J., Maughan W.L., Sagawa K., Accuracy of volume measurement by conductance catheter in isolated, ejecting canine hearts, Circulation, 72, pp. 440-447, (1985)
[7] Mur G., Baan J., Computation of the input impedances of a catheter for cardiac volumetry, IEEE Trans Biomed Eng BME, 31, pp. 448-453, (1984)
[8] Yamori Y., Tarazi R.C., Ooshima A., Effect of beta-receptor-blocking agents on cardiovascular structural changes in spontaneous and noradrenaline-induced hypertension in rats., Clin Sci (Lond), 59, pp. 457s-462s, (1980)
[9] Saku K., Fujio M., Yamamoto K., Ying H., Tashiro N., Harada R., Okabe M., Arakawa K., Cardiac function of WHHL rabbit, an animal model of familial hypercholesterolemia, Artery, 17, 5, pp. 271-280, (1990)
[10] Stephan M.F., Minashi T., Cho S., Renee D., Sonnenblick E.H., Microvascular spasm in the cardiomyopathic Syrian hamster: A preventable cause of focal myocardial necrosis, Circulation, 66, pp. 342-354, (1982)

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