AGE-ASSOCIATED CHANGE OF 8-HYDROXYGUANINE REPAIR ACTIVITY IN CULTURED HUMAN FIBROBLASTS

被引：22

作者：

HIRANO, T

YAMAGUCHI, Y

HIRANO, H

KASAI, H

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT ENVIRONM ONCOL,KITAKYUSHU,FUKUOKA 807,JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH,DEPT BIOCHEM,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2407

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

8-hydroxyguanine (8-OH-Gua) is a major oxidative DNA damage product. Its repair activity was determined in the human fibroblast cell line, TIG-3, during the aging process. The repair activity increased in the first part of the aging process and decreased in the latter part. The highest repair activity was observed at the age of 30 PDL. These results suggest that the defense capacity for replication errors due to oxidative DNA damage increases greatly when the cells are rapidly dividing, (C) 1995 Academic Press, Inc.

引用

页码：1157 / 1162

页数：6

共 22 条

[1]

BELL ML, 1984, MUTAT RES, V132, P51

[2] AN IMPROVED METHOD FOR THE PREPARATION OF THE PHOSPHORAMIDITES OF MODIFIED 2'-DEOXYNUCLEOTIDES - INCORPORATION OF 8-OXO-2'-DEOXY-7H-GUANOSINE INTO SYNTHETIC OLIGOMERS [J].