SOME PHARMACOLOGICAL AND BIOCHEMICAL EFFECTS OF PARTIALLY PURIFIED PLANETOCIN

被引：3

作者：

COBBIN, DM

TEMPLE, DM

机构：

[1] Department of Pharmacology, The University of Sydney, Sydney

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY | 1969年 / 28卷 / 03期

关键词：

angiotensin; bradykinin; oxytocin; peptidase; Periplaneta americana; planetocin; smooth muscle inhibition; uterine stimulant;

D O I：

10.1016/0010-406X(69)90572-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Planetocin, a powerful uterine stimulant present in aqueous extracts of the gut of Periplaneta americana, has been partially purified principally by gel filtration columns. 2. 2. Three main actions have been observed with such material: (a) a slowly developing, prolonged stimulation of the rat uterus; (b) a slowly developing inhibition of other smooth muscle preparations; (c) a peptidase-like action upon various peptides. 3. 3. Gel filtration and gel electrophoresis do not give even a partial separation of these actions. 4. 4. All three actions have the same heat lability. 5. 5. It seems possible that all three actions may be the direct or indirect result of peptidase activity. © 1969.

引用

页码：1357 / +

共 11 条

[1] ADRENERGIC PROPERTIES OF THE COCKROACH CORPUS CARDIACUM [J].