SPECIFIC RADIOIMMUNOASSAY OF AMITRIPTYLINE AND NORTRIPTYLINE

被引：21

作者：

BRUNSWICK, DJ ^{[1
]}

NEEDELMAN, B ^{[1
]}

MENDELS, J ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT PSYCHIAT,PHILADELPHIA,PA 19104

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 7卷 / 04期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb00943.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Antisera to nortriptyline were prepared by immunizing rabbits with N‐ succinylnortriptyline‐bovine serum albumin conjugate. 2 A sensitive radioimmunoassay has been developed for the tricyclic antidepressants amitriptyline and nortriptyline. 3 amitriptyline and nortriptyline are separated from each other and from interfering metabolites before assay. 4 Using [3H]‐imipramine and [3H]‐succinylnortriptyline as tracers the radioimmunoassay can measure amitriptyline and nortriptyline levels down to 2–3 ng/ml using 0.05 ml plasma sample. 5 Agreement between the radioimmunoassay and a gas‐chromatographic assay was excellent for both amitriptyline and nortriptyline. 1979 The British Pharmacological Society

引用

页码：343 / 348

页数：6

共 18 条

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