REGULATION OF HIGH-AFFINITY CHOLINE UPTAKE

被引：37

作者：

BREER, H

KNIPPER, M

机构：

[1] University of Hohenheim, Institute of Zoophysiology, Stuttgart

来源：

JOURNAL OF NEUROBIOLOGY | 1990年 / 21卷 / 02期

关键词：

D O I：

10.1002/neu.480210202

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

High affinity uptake of choline, the rate‐limiting, regulatory step for the synthesis of acetylcholine (ACh), was found to be regulated via presynaptic auto‐ and hetero‐receptors. The transport rate was reduced by a muscarinic agonist and neuropeptides, but was significantly enhanced by octopamine. Intracellular messengers, including cyclic nucleotides, appear to modulate the transport activity, apparently by activating specific protein kinases. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：269 / 275

页数：7

共 27 条

[1] CHANGES IN SYNAPTOSOMAL HIGH-AFFINITY CHOLINE UPTAKE FOLLOWING ELECTRICAL-STIMULATION OF GUINEA-PIG CORTICAL SLICES - EFFECT OF ATROPINE AND PHYSOSTIGMINE [J].