KINETIC RESOLUTION OF (+/-)-4-ACYLOXY-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYLISOQUINOLINES BY USE OF IMMOBILIZED LIPASES IN ORGANIC-SOLVENTS

被引：6

作者：

HOSHINO, O ^{[1
]}

ITOH, K ^{[1
]}

UMEZAWA, B ^{[1
]}

AKITA, H ^{[1
]}

OISHI, T ^{[1
]}

机构：

[1] RIKEN INST PHYS & CHEM RES, WAKO, SAITAMA 35101, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 12期

关键词：

(+/-)-4-ACYLOXYTETRAHYDROISOQUINOLINE; 4S-(+)-TETRAHYDROISOQUINOLIN-4-OL; 4R-(-)-4-ACYLOXYTETRAHYDROISOQUINOLINE; 4R-(-)-TETRAHYDROISOQUINOLIN-4-OL; CANDIDA-CYLINDRACEA; CELITE-IMMOBILIZED LIPASE; CYCLOHEXANE; ISOOCTANE; KINETIC RESOLUTION; R-(+)-MTPA ESTER;

D O I：

10.1248/cpb.38.3273

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Kinetic resolution of (+/-)-4-acyloxytetrahydroisoquinolines (5-7) by use of lipases immobilized on Celite in isooctane or cyclohexane saturated with water was carried out to give 4S-(+)-tetrahydroisoquinolin-4-ol (8) in a high optical purity. The absolute configuration of (+)-8 was determined by comparison of the spectral data and specific rotation with those of authentic 4R-(-)-tetrahydroisoquinolin-4-ol (8) derived from R-(-)-epinephrine (9).

引用

页码：3273 / 3276

页数：4

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