THE ENANTIOMERS OF 1-BETA-ADENYL-2-ALPHA-HYDROXY-3-BETA-HYDROXYMETHYL-CYCLOBUTANE

被引：5

作者：

BASCHANG, G

INDERBITZIN, W

机构：

[1] Research Department, Pharmaceuticals Division, Ciba - Geigy Ltd., 4002 Basle, CH

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 02期

关键词：

CARBA-NUCLEOSIDES; CHROMATOGRAPHY; OSMYLATION; ENZYMATIC ACETYLATION; CYCLOSULFATE;

D O I：

10.1016/S0957-4166(00)80187-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantiomers of 1-beta-adenyl-2-alpha-hydroxy-3-beta-hydroxymethyl-cyclobutane have been separated by chromatography of their 2-(N-BOC-prolyl)-3-trityloxymethyl-derivatives. The (-)-enantiomer has been obtained from 1.2-dihydroxy-3-trityloxymethyl-cyclobutane enriched by acetylation of the racemate with Pseudomonas fluorescens lipase.

引用

页码：193 / 196

页数：4

共 7 条

[1]

ICHIKAWA Y, 1989, Patent No. 330992

[2]

ISHIKAWA Y, 1989, J CHEM SOC CHEM COMM, P1919

[3] CYCLIC SULFATES CONTAINING ACID-SENSITIVE GROUPS AND CHEMOSELECTIVE HYDROLYSIS OF SULFATE ESTERS [J].