IMMUNOBIOLOGICAL STUDIES ON EXPERIMENTAL VISCERAL LEISHMANIASIS .1. CHANGES IN LYMPHOID ORGANS AND THEIR POSSIBLE ROLE IN PATHOGENESIS

被引:52
作者
SAHA, B
NANDAROY, H
PAKRASHI, A
CHAKRABARTI, RN
ROY, S
机构
[1] INDIAN INST CHEM BIOL, DIV LEISHMANIA, 4 RAJA SC MULLICK RD, Kolkata 700032, W BENGAL, INDIA
[2] CHITTARANJAN NATL CANC INST, Kolkata, INDIA
关键词
D O I
10.1002/eji.1830210307
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Studies were carried out to determine changes in lymphoid organs i.e. spleen, lymph node and bone marrow (BM) in progressive experimental visceral leishmaniasis. Mononuclear phagocytes in the BM were increased; spleens showed a hypercellularity coupled with a rise in parasite burden while secondary follicles with no apparent depletion of paracortex were seen in the lymph node. This enhanced proliferation of mononuclear phagocytes in the BM and probably their subsequent recruitment in the spleen could be induced in naive recipients by injecting nylon wool-purified lymph node cells derived from infected mice together with sonicated leishmanial antigen(s). Similar changes could also be induced in the BM of naive recipients by injecting serum of infected mice. In control experiments where both donor and recipients were uninfected such changes were not apparent. A working hypothesis is proposed to delineate the role of lymphoid organs in the pathogenesis of experimental visceral leishmaniasis.
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页码:577 / 581
页数:5
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