EFFECT OF ATRIAL-NATRIURETIC-PEPTIDE AND ON ATRIOPEPTINS ON THE HUMAN ISOLATED BRONCHUS - COMPARISON WITH THE REACTIVITY OF THE GUINEA-PIG ISOLATED TRACHEA

被引：18

作者：

CANDENAS, ML

NALINE, E

PUYBASSET, L

DEVILLIER, P

ADVENIER, C

机构：

[1] UNIV PARIS 05,PHARMACOL RESP LAB,15 RUE ECOLE MED,F-75270 PARIS 06,FRANCE

[2] BIOPROJET,F-75004 PARIS,FRANCE

来源：

PULMONARY PHARMACOLOGY | 1991年 / 4卷 / 02期

关键词：

D O I：

10.1016/0952-0600(91)90062-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ANF, ANF7-28 and atriopeptins (AP1, AP2 and AP3) (10(-11) to 3 x 10(-7) M) induce a relaxant response on the guinea-pig isolated trachea, which is partially potentiated by the enkephalinase inhibitor thiorphan 10(-5)M but is unmodified by epithelium removal. Conversely, these drugs were found to be without any significant relaxant effect on the isolated human bronchus. Several hypotheses, such as the activation of ANF receptors not located on airway smooth muscle or an indirect effect of ANF in vivo are suggested to explain the discrepancy between these in vitro results and those of clinical trials in asthmatic subjects.

引用

收藏

页码：120 / 125

页数：6

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