THERAPEUTIC EFFECTS OF LIPOSOMAL ADRIAMYCIN IN COMBINATION WITH TUMOR-NECROSIS-FACTOR-ALPHA

被引：9

作者：

MARUO, Y ^{[1
]}

KONNO, H ^{[1
]}

BABA, S ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, DEPT SURG 2, HAMAMATSU, SHIZUOKA 431-31, JAPAN

来源：

JOURNAL OF SURGICAL ONCOLOGY | 1992年 / 49卷 / 01期

关键词：

LIPOSOMES; RTNF-ALPHA; TUMOR GROWTH CURVE; TUMOR WEIGHT;

D O I：

10.1002/jso.2930490106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liposomes as drug carriers in cancer chemotherapy have attracted considerable interest. To enhance the therapeutic effect of Adriamycin entrapped in liposomes (Lip-ADM) on human solid tumors, we investigated the therapeutic effects of Lip-ADM in combination with recombinant human tumor necrosis factor-alpha (rTNF-alpha), which is known to have specific effects on tumor vasculature. rTNF-alpha or saline solution was injected intravenously into nude mice bearing a human colon cancer strain, HC-1, at 1 hour before intravenous administration of Lip-ADM. The significant therapeutic effect of Lip-ADM in combination with rTNF-alpha was demonstrated by the evaluation with tumor growth curve and the actual tumor weights, in comparison with groups of mice treated with saline solution, rTNF-alpha alone, or with a Lip-ADM after saline. Levels of Adriamycin in tumor tissue in the Lip-ADM in combination with rTNF-alpha-treated group were higher than those in Lip-ADM with saline solution-treated group.

引用

页码：20 / 24

页数：5

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