EVIDENCE FOR GENETIC DETERMINATION IN HUMAN TWINS OF OLFACTORY THRESHOLDS FOR A STANDARD ODORANT

被引：45

作者：

GROSSISSEROFF, R

OPHIR, D

BARTANA, A

VOET, H

LANCET, D

机构：

[1] WEIZMANN INST SCI, DEPT MEMBRANE RES & BIOPHYS, IL-76100 REHOVOT, ISRAEL

[2] HEBREW UNIV JERUSALEM, FAC AGR, DEPT AGR ECON, JERUSALEM, ISRAEL

[3] MEIR HOSP, DEPT OTOLARYNGOL, KEFAR SAVA, ISRAEL

来源：

NEUROSCIENCE LETTERS | 1992年 / 141卷 / 01期

关键词：

OLFACTORY THRESHOLD; TWINS; ISOAMYL ACETATE; ANDROSTENONE; INDIVIDUAL DIFFERENCE; GENETIC DETERMINATION;

D O I：

10.1016/0304-3940(92)90347-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Olfactory thresholds for four odorants were determined in groups of monozygotic and dizygotic human twins. Odorants were presented in an ascending dilution series in odorless solvent, using a three-way forced choice method. For two of the tested odorants, 5-alpha-androst-16-en-3-one and isoamyl acetate, the thresholds showed a strong genetic component. This was demonstrated by respective values of 0.78 and 0.73 for the intraclass correlation difference, and of z = 3.69 and z = 2.71 in a within-pair difference analysis. The results for isoamyl acetate are novel, and suggest that genetic polymorphism in the affinity of odorant receptor proteins contributes to the (nearly normal) threshold distribution for this odorant.

引用

页码：115 / 118

页数：4

共 16 条

[1] MEASUREMENT OF SPECIFIC ANOSMIA [J].