SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SOME NEW PYRIDAZINONES

被引：13

作者：

CORSANO, S ^{[1
]}

STRAPPAGHETTI, G ^{[1
]}

CODAGNONE, A ^{[1
]}

SCAPICCHI, R ^{[1
]}

MARUCCI, G ^{[1
]}

机构：

[1] UNIV CAMERINO,DEPT CHEM SCI,I-62032 CAMERINO,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 05期

关键词：

PYRIDAZINONE; ALPHA-ADRENOCEPTORS; ALPHA-ANTAGONIST; STRUCTURE-ACTIVITY RELATIONSHIP; RAT VAS DEFERENS; HYPOTENSIVE ACTIVITY;

D O I：

10.1016/0223-5234(92)90189-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of piperazinyl-pyridazinones is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens. For compounds 7, 17 and 18, the hypotensive activity was also evaluated.

引用

收藏

页码：545 / 549

页数：5

相关论文

共 9 条

[1]

ANGELETTI E, 1957, GAZZ CHIM ITAL, V87, P1115

[2] SYNTHESIS AND ANTIHYPERTENSIVE PROPERTIES OF BENZODIOXANE-PYRIDAZINONES AND BENZODIOXANE-DIHYDROPYRIDAZINONES [J].

CORSANO, S ;

STRAPPAGHETTI, G ;

CODAGNONE, A .

ARCHIV DER PHARMAZIE, 1989, 322 (11) :833-835

[3] 6-PHENYL-4,5-DIHYDRO-3(H-2)-PYRIDAZINONES - SERIES OF HYPOTENSIVE AGENTS [J].

CURRAN, WV ;

ROSS, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) :273-281

[4] SELECTIVITY OF BLOCKING-AGENTS FOR PRESYNAPTIC AND POSTSYNAPTIC ALPHA-ADRENOCEPTORS [J].

DOXEY, JC ;

SMITH, CFC ;

WALKER, JM .

BRITISH JOURNAL OF PHARMACOLOGY, 1977, 60 (01) :91-96

[5] PHARMACOLOGICAL CHARACTERIZATION OF PRESYNAPTIC ALPHA-ADRENOCEPTOR IN RAT VAS-DEFERENS [J].

DREW, GM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1977, 42 (02) :123-130

[6] CARDIOTONIC AGENTS .2. SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIPS OF 4,5-DIHYDRO-6-[4-(1H-IMIDAZOL-1-YL)PHENYL]-3(2H)-PYRIDAZINONES - A NEW CLASS OF POSITIVE INOTROPIC AGENTS [J].

SIRCAR, I ;

DUELL, BL ;

BOBOWSKI, G ;

BRISTOL, JA ;

EVANS, DB .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) :1405-1413

[7]

STRAPPAGHETTI G, 1986, FARMACO, V41, P794

[8] 6-ARYL-4,5-DIHYDRO-3(2H)-PYRIDAZINONES - A NEW CLASS OF COMPOUNDS WITH PLATELET-AGGREGATION INHIBITING AND HYPOTENSIVE ACTIVITIES [J].

THYES, M ;

LEHMANN, HD ;

GRIES, J ;

KONIG, H ;

KRETZSCHMAR, R ;

KUNZE, J ;

LEBKUCHER, R ;

LENKE, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :800-807

[9]

ZIKOLOVA SV, 1972, T NAUCHNOIZSLED KHIM, V8, P41